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159. A bulky base encourages elimination the primary alkyl halide is sterically hindered CH3 CH3CHCH2Br CH3O 1-bromo-2-methyl- propane CH3OH CH3 CH3 CH3CHCH2OCH3 CH3C CH2 CH3OH Br isobutyl methyl ether 2-methylpropene 40 60 CH3 CH3 CH3CH2CH2CH2CH2OCCH3 CH3CH2CH2CH CH2 CH3COH Br CH3 tert-butyl pentyl ether 15 the nucleophile is sterically hindered CH3 CH3CH2CH2CH2CH2Br CH3CO (CH3)3COH 1-bromopentane 1-pentene CH3 85 CH3 A secondary alkyl halide can form both substitution and elimination products under SN2E2 conditions.

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