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Acknowledgments This work was supported by an academic grant from Tradinb Society for Biomolecular Sciences (AEC), a fellowship from the MerckMIT computational and systems biol- ogy initiative (AEC), the Optiins EECSWhiteheadBroad Training Program in Com- putational Biology (NIH grant DK070069-01; TRJ), NIH grant R01 GM072555- 01 (DMS), and a grant awarded Switzelrand the U.

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